Anoreigenic. It is indicated in the treatment of overweight patients (body mass index equal to or greater than 27 kg / m2 [patients with short stature, body mass index equal to or greater than 25 kg / m2]); as well as in patients with obesity (body mass index equal to or greater than 30 kg / m2); with any associated pathology and who have not responded to diet and physical activity appropriately. It is suggested to carry out a program of physical activity and diet simultaneously with treatment with Clobenzorex.
Clobenzorex is a sympathomimetic amine that acts on the ventrolateral nucleus of the hypothalamus, increasing the release of norepinephrine and dopamine in the synaptic spaces and decreasing their reuptake in presynaptic nerve endings, so the net effect is an increase in norepinephrine concentrations. and dopamine. Norepinephrine basically acts to curb appetite by activating alpha 4 and beta 1 receptors in the hypothalamic nuclei. Three main mechanisms have been identified by which drugs contribute to weight and body fat reduction:
a) Decreased food intake.
b) Specific metabolic modifications.
c) Increased energy expenditure.
Clobenzorex is well absorbed from the digestive tract, the peak concentration of Clobenzorex is reached 50 to 120 minutes after the first dose and the concentration varies from 8 to 47 ng/ml. Elimination is via the kidneys in the form of para-hydroxyclobenzorex.
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